Fig. 7From: Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug deliveryNP influence release of chemokines, cytokines and growth factors in 3D human neural models. Graphs showing the levels of different secreted mediators after exposure to Au-SC (6 μg/mL), Au-PEG (20 μg/mL) and PLA-NP (20 μg/mL) for 24 and 72 h in comparison to untreated control spheroids. a 3D LUHMES (MIP-1β, IL-10, IL-12p70, TNFα, bFGF and VEGF) and b BrainSpheres (IL-1ra, IL-10, IL-12p70, GM-CSF, bFGF and VEGF). Data were collected from three independent experiments with three technical replicates and represents mean (± SEM). One-way ANOVA with Bonferroni’s multiple comparisons post-test was used to analyze the statistical significance (*p < 0.05)Back to article page