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Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: Subchronic exposure to titanium dioxide nanoparticles modifies cardiac structure and performance in spontaneously hypertensive rats

Fig. 6

Ultrastructural features of the alveolar lung parenchyma from a representative untreated CTRL and TiO2-NPs treated SHR. a a type I pneumocyte (PI) and three capillaries (*) are present in the alveolar septum separating air spaces (As) in CTRL lung. b several TiO2-NPs are present in the cytoplasm of a large alveolar macrophage showing, in addition to vacuoles and microvescicles, onionskin-like multimembrane ultrastructures suggestive of autophagy. The area inscribed by white rectangle is shown at higher magnification in the inset. c an aggregate of electrondense TiO2-NPs is located nearby an endothelial cell lining the lumen of a capillary recognizable by the red blood cell (RBC). The white rectangle inscribes an area shown at higher magnification in d to document that TiO2-NPs are not yet internalized. e internalization of TiO2-NPs in a capillary endothelial cell that is better appreciable at higher magnification in (f). Scale Bars: a 5 μm, b, c, e: 2 μm, d, f: 500 nm

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