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Table 4 Absolute and relative organ weights of TiO2 nanoparticles exposed pregnant females

From: Titanium dioxide nanoparticles oral exposure to pregnant rats and its distribution

  TiO2 nanoparticles (mg/kg)
0 100 300 1000
Pregnant Females (N) 12 12 12 12
Adrenal glands (g) 0.08 ± 0.010a 0.07 ± 0.010 0.07 ± 0.010 0.07 ± 0.009
Organ to terminal body weight ratio (%) 0.02 ± 0.003 0.02 ± 0.003 0.02 ± 0.003 0.02 ± 0.002
Brain (g) 1.86 ± 0.080 1.87 ± 0.089 1.83 ± 0.064 1.90 ± 0.045
Organ to terminal body weight ratio (%) 0.49 ± 0.047 0.49 ± 0.037 0.47 ± 0.021 0.50 ± 0.024
Heart (g) 1.09 ± 0.106 1.10 ± 0.087 1.12 ± 0.066 1.10 ± 0.103
Organ to terminal body weight ratio (%) 0.29 ± 0.028 0.28 ± 0.026 0.29 ± 0.018 0.29 ± 0.026
Kidneys (g) 2.05 ± 0.211 2.03 ± 0.160 2.06 ± 0.189 2.06 ± 0.192
Organ to terminal body weight ratio (%) 0.54 ± 0.049 0.52 ± 0.034 0.53 ± 0.047 0.55 ± 0.050
Liver (g) 14.19 ± 1.000 14.48 ± 1.039 15.16 ± 1.186 14.70 ± 0.823
Organ to terminal body weight ratio (%) 3.75 ± 0.229 3.75 ± 0.185 3.89 ± 0.237 3.88 ± 0.138
Pituitary gland (g) 0.01 ± 0.002 0.01 ± 0.003 0.01 ± 0.002 0.01 ± 0.002
Organ to terminal body weight ratio (%) 0.004 ± 0.0006 0.004 ± 0.0006 0.004 ± 0.0005 0.004 ± 0.0005
Spleen (g) 0.70 ± 0.116 0.69 ± 0.073 0.73 ± 0.115 0.71 ± 0.077
Organ to terminal body weight ratio (%) 0.19 ± 0.028 0.18 ± 0.018 0.19 ± 0.028 0.19 ± 0.019
Lung 1.35 ± 0.105 1.33 ± 0.112 1.35 ± 0.122 1.28 ± 0.107
Organ to terminal body weight ratio (%) 0.36 ± 0.032 0.35 ± 0.034 0.35 ± 0.030 0.34 ± 0.021
Right ovary (g) 0.06 ± 0.012 0.07 ± 0.01 0.06 ± 0.011 0.06 ± 0.011
Organ to terminal body weight ratio (%) 0.02 ± 0.003 0.02 ± 0.003 0.02 ± 0.003 0.02 ± 0.003
Left ovary (g) 0.06 ± 0.009 0.06 ± 0.011 0.06 ± 0.014 0.06 ± 0.012
Organ to terminal body weight ratio (%) 0.02 ± 0.002 0.01 ± 0.003 0.02 ± 0.004 0.02 ± 0.003
Thymus (g) 0.40 ± 0.084 0.37 ± 0.076 0.43 ± 0.066 0.37 ± 0.080
Organ to terminal body weight ratio (%) 0.11 ± 0.023 0.10 ± 0.019 0.11 ± 0.0175 0.10 ± 0.023
  1. aValues are presented as mean ± S.D
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Particle and Fibre Toxicology

ISSN: 1743-8977

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