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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Mitsui-7, heat-treated, and nitrogen-doped multi-walled carbon nanotubes elicit genotoxicity in human lung epithelial cells

Fig. 5

Mitotic spindle disruption and fragmented centrosomes were observed in BEAS-2B cells exposed to each MWCNT material. a-c DNA is blue, centrosomes are green, and mitotic spindle is red in a normal (a), monopolar (b), and multipolar (c) spindle morphology. d Centrosome fragmentation was significantly increased. MWCNT-7 white, MWCNT-HT gray, and MWCNT-ND black bar. V2O5 was used as a positive control, 0.316 μg/mL. Magnification bar is 10 μm. *indicates significantly different from control, p < 0.05. ¥ indicates significantly different from other MWCNT materials at same dose, p < 0.05; ± SD

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