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Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: Mitsui-7, heat-treated, and nitrogen-doped multi-walled carbon nanotubes elicit genotoxicity in human lung epithelial cells

Fig. 6

Fragmentation and translocation of the centromeres of chromosomes 1 & 4 in SAEC exposed to MWCNT material. a Nuclei of cells exposed to MWCNT-7 material are stained blue, chromosome 1 in red, and chromosome 4 in green. Magnification bar is 30 μm. b Region of interest, yellow arrow points to centromere fragment of chromosome 4. Red arrow points to chromosome 4 inserted into chromosome 1. Green arrow points to translocation between centromeres of both chromosomes. Magnification bar is 20 μm. c & d) Graphical representation of centromere fragmentations (c) and translocations (d). MWCNT-7 white, MWCNT-HT gray, and MWCNT-ND black bars. V2O5 was used as a positive control, 3.16 μg/mL. * indicates significantly different from control, p < 0.05. ¥ indicates significantly different from other MWCNT materials at same dose, p < 0.05; ± SD

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