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Table 2 Mitotic aberrations in BEAS-2B cells exposed to MWCNT material

From: Mitsui-7, heat-treated, and nitrogen-doped multi-walled carbon nanotubes elicit genotoxicity in human lung epithelial cells

Treatment Mitotic Index Spindle Aberration Monopolar Multipolar Centrosome Fragmentation
Control 7 ± 3 7 ± 3 2 ± 2 5 ± 1 3 ± 3
V2O5 3 ± 1* 14 ± 1 8 ± 2 6 ± 2 10 ± 2*
MWCNT-7 (μg/mL) 0.024 6 ± 1 17 ± 7* 10 ± 9 7 ± 3 18 ± 7*
0.24 5 ± 3 17 ± 2* 10 ± 6 7 ± 5 18 ± 4*
2.4 5 ± 3 7 ± 6 5 ± 4 2 ± 2 17 ± 12*
24 2 ± 2* 9 ± 7 2 ± 4 4 ± 4 10 ± 10
MWCNT-HT (μg/mL) 0.024 6 ± 3 14 ± 7 6 ± 5 8 ± 4 25 ± 4*
0.24 6 ± 3 20 ± 20* 12 ± 16 8 ± 5 22 ± 12*
2.4 8 ± 5 20 ± 12* 15 ± 15 5 ± 3 23 ± 10*
24 4 ± 1 18 ± 5* 14 ± 5 4 ± 1 27 ± 15*
MWCNT-ND (μg/mL) 0.024 6 ± 3 13 ± 9 7 ± 7 5 ± 2 23 ± 8*
0.24 5 ± 4 24 ± 12* 15 ± 11 9 ± 3 18 ± 6*
2.4 5 ± 3 15 ± 11 9 ± 11 6 ± 4 23 ± 10*
24 3 ± 3* 6 ± 5 3 ± 6 3 ± 5 14 ± 12
  1. This table includes the percentage of mitotic aberrations after exposure to MWCNT material in a dose response and 0.316 μg/mL V2O5, positive control, for 24 h. Spindle aberration is reported as the sum of the percentage of monopolar and multipolar mitotic spindles. *indicates significantly different from control, p < 0.05; ± SD