Mitsui-7, heat-treated, and nitrogen-doped multi-walled carbon nanotubes elicit genotoxicity in human lung epithelial cells

Table 2 Mitotic aberrations in BEAS-2B cells exposed to MWCNT material

Treatment		Mitotic Index	Spindle Aberration	Monopolar	Multipolar	Centrosome Fragmentation
Control		7 ± 3	7 ± 3	2 ± 2	5 ± 1	3 ± 3
V₂O₅		3 ± 1*	14 ± 1	8 ± 2	6 ± 2	10 ± 2*
MWCNT-7 (μg/mL)	0.024	6 ± 1	17 ± 7*	10 ± 9	7 ± 3	18 ± 7*
	0.24	5 ± 3	17 ± 2*	10 ± 6	7 ± 5	18 ± 4*
	2.4	5 ± 3	7 ± 6	5 ± 4	2 ± 2	17 ± 12*
	24	2 ± 2*	9 ± 7	2 ± 4	4 ± 4	10 ± 10
MWCNT-HT (μg/mL)	0.024	6 ± 3	14 ± 7	6 ± 5	8 ± 4	25 ± 4*
	0.24	6 ± 3	20 ± 20*	12 ± 16	8 ± 5	22 ± 12*
	2.4	8 ± 5	20 ± 12*	15 ± 15	5 ± 3	23 ± 10*
	24	4 ± 1	18 ± 5*	14 ± 5	4 ± 1	27 ± 15*
MWCNT-ND (μg/mL)	0.024	6 ± 3	13 ± 9	7 ± 7	5 ± 2	23 ± 8*
	0.24	5 ± 4	24 ± 12*	15 ± 11	9 ± 3	18 ± 6*
	2.4	5 ± 3	15 ± 11	9 ± 11	6 ± 4	23 ± 10*
	24	3 ± 3*	6 ± 5	3 ± 6	3 ± 5	14 ± 12

This table includes the percentage of mitotic aberrations after exposure to MWCNT material in a dose response and 0.316 μg/mL V₂O₅, positive control, for 24 h. Spindle aberration is reported as the sum of the percentage of monopolar and multipolar mitotic spindles. *indicates significantly different from control, p < 0.05; ± SD

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