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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: HIF-1α is a key mediator of the lung inflammatory potential of lithium-ion battery particles

Fig. 1

LCO induces stronger lung toxicity than silica particles. C57BL/6Jrj mice were treated with an oro-pharyngeal aspiration of NaCl (control), 0.1, 0.5 or 2 mg LCO or crystalline silica (Sil). Mice were euthanized after 2 months. Inflammatory cell infiltration (a) was measured in BAL; HIF-1α (c) in lung homogenates. Severity of fibrotic responses was scored according to Hübner et al. (2008) on lung sections stained with Sirius red (b). Lung sections stained with Sirius red (magnification 10x and 200x) (d). *P < 0.05, **P < 0.01 and ***P < 0.001 relative to NaCl-treated mice (one-way ANOVA followed by a Dunnett’s multiple comparison, N = 1, n = 5, means ± SEM)

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