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Fig. 2 | Particle and Fibre Toxicology

Fig. 2

From: HIF-1α is a key mediator of the lung inflammatory potential of lithium-ion battery particles

Fig. 2

Lung inflammatory and fibrotic responses induced by LIB particles. C57BL/6Jrj mice were treated with an oro-pharyngeal aspiration of NaCl (control), 0.5, 1 or 2 mg LCO, NMC 1:1:1, NMC 6:2:2, NMC 8:1:1, NCA or Co3O4. Mortality is shown in survival curves (a). Surviving mice were euthanized after 2 months. Inflammatory cell infiltration (b) was measured in BALF. Fibrotic response (c) severity was scored according to Hübner et al. (2008). HIF-1α (d) was measured in lung homogenates. Number of surviving mice is indicated for each condition above the columns (b). *P < 0.05, **P < 0.01 and ***P < 0.001 relative to NaCl-treated mice (one-way ANOVA followed by a Dunnett’s multiple comparison or t test, N = 1, n = 4–6 (treated mice), means ± SEM)

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