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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: HIF-1α is a key mediator of the lung inflammatory potential of lithium-ion battery particles

Fig. 5

HIF-1α stabilization after LCO acts upstream of inflammation. C57BL/6Jrj or IL-1β KO mice were treated with an oro-pharyngeal aspiration of NaCl (control), 2 mg LCO or crystalline silica (Sil). Mice were euthanized after 3 days. Alveolar inflammatory cell infiltration (a) and neutrophils (b) were assessed in the BAL, and IL-6 (c) was measured in BALF; HIF-1α in lung homogenates (d). *P < 0.05, **P < 0.01 and ***P < 0.001 (t-test between WT and IL-1β KO mice for each condition, N = 1, n = 5, means ± SEM)

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