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Fig. 10 | Particle and Fibre Toxicology

Fig. 10

From: Role of chemical composition and redox modification of poorly soluble nanomaterials on their ability to enhance allergic airway sensitisation in mice

Fig. 10

Examples of observed ectopic lymphoid structures in lungs. Light photomicrographs of G5, principally large-diameter, proximal axial airway from the lungs of OVA+Co3O4(0% Fe2O3) NP treated mice (a, b, c), and OVA+ Co3O4(25% Fe2O3) NP-treated mice (d, e, f). Lung tissue sections for A and D were stained for murine major basic protein, a specific marker for eosinophils (red chromogen-stained cells; arrow 1). Tissue sections B and E were stained with Alcian Blue/Periodic Acid Schiff (AB/PAS) for neutral and acidic mucosubstances (dark magenta stain; arrow 2) in mucous cells of the airway epithelium. Tissue sections C and F were stained with hematoxylin and eosin (H&E). arrow 3: ectopic lymphoid structures (ELS), arrow 4: Co3O4 NP-laden alveolar macrophages; aa: axial airway lumen; a: alveolus

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Particle and Fibre Toxicology

ISSN: 1743-8977

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