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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Inhaled gold nanoparticles cause cerebral edema and upregulate endothelial aquaporin 1 expression, involving caveolin 1 dependent repression of extracellular regulated protein kinase activity

Fig. 4

Cav1 is of central importance to transduce signal after Au-NP exposure. Representative images (a) and quantitative data proved 10 μM GDC-0068 and 10 μM PF-573228 has no obvious influence on Au-NP-mediated Cav1 accumulation (b), but significantly reversed Au-NP-mediated ERK de-phosphorylation (c). PF-573228 decreased the phosphorylation of FAK and AKT induced by Au-NPs, suggested FAK may be an upstream effector (d). GDC-0068 caused a robust phospho-AKT, which is the signature of ATP competitive inhibitors of AKT, but failed to prevent Au-NP-induced FAK phosphorylation (e). (* p < 0.05, ** p < 0.01, and *** p < 0.001 indicates statistically significant difference from the control group; # p < 0.05, ## p < 0.01, and ### p < 0.001 indicates statistically significant difference from the Au-NP-treated group. The ns means without statistical difference.)

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Particle and Fibre Toxicology

ISSN: 1743-8977

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