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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Inhaled gold nanoparticles cause cerebral edema and upregulate endothelial aquaporin 1 expression, involving caveolin 1 dependent repression of extracellular regulated protein kinase activity

Fig. 5

Inhaled Au-NPs increased water permeability in vivo. After intranasal Au-NP administration (3 mg/kg) for 3–14 days, ICR mice were gained in their brain wet weight (a), as well as the water content in brain (b). (* p < 0.05, and ** p < 0.01 indicates statistically significant difference from the control group, N = 8). By using non-invasive method, Au-NP-mediated brain edema has been affirmed in T2 MRI scanning. An elevation in T2 value was detected in day 3–14, as compared to control animals

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Particle and Fibre Toxicology

ISSN: 1743-8977

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