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Fig. 7 | Particle and Fibre Toxicology

Fig. 7

From: Inhaled gold nanoparticles cause cerebral edema and upregulate endothelial aquaporin 1 expression, involving caveolin 1 dependent repression of extracellular regulated protein kinase activity

Fig. 7

Inhaled Au-NPs caused mild tissue damages in the brain. a Briefly, brain slices were made freshly, and incubated with 2% TTC solution as described in Materials and Methods. Representative images showed in Au-NP-treated groups, the reactivity of brain tissues to metabolize TTC to red-colored, lipid-soluble formazan were decreased, suggested the appearance of mild, focal tissue damages. b Histopathological lesions of brain were accessed by H&E staining and TUNEL assay. Samples of Au-NP-treated groups had a weak reactivity to eosin, and the morphology of neurons are swelling with a finely, adjacent vacuolated region around the cell body. However, no darkly stained TUNEL-positive cells were found

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Particle and Fibre Toxicology

ISSN: 1743-8977

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