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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate

Fig. 1

Cytotoxicity in human liver MT following exposures to a panel of engineered NMs for up 3 weeks as measured by AK release via ToxiLight™ cytotoxicity assay (NM treatments 1.25–10 μg/ml). a Experiment A - 7 days of NM dosing following 2 weeks of recovery; b Experiment B - 14 days of NM dosing following 1 week of recovery and c Experiment C - 21 days of NM dosing with no recovery period. The Triton data depicts 100% cell death ± SEM. The values represent mean ± SEM (n = 3) with significance indicated by * p < 0.05 and ** p < 0.005 for ageing effects compared to day 1 negative control, $ p < 0.05 and $$ p < 0.005 signifying NM induced and £ p < 0.05 and ££ p < 0.005 NM-induced effects in addition to the ageing effect

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