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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: Silicon dioxide nanoparticles induce insulin resistance through endoplasmic reticulum stress and generation of reactive oxygen species

Fig. 1

Characterization of fumed SiO2 NPs (nanoparticles), stober SiO2 NPs, fumed SiO2 FPs (fine-particles), and stober SiO2 FPs in the orally administered dose, silicon concentrations in mouse tissues, and absorption of SiO2 NPs in mouse tissues. a SEM of fumed SiO2 NPs, stober SiO2 NPs, SiO2 FPs, and stober SiO2 FPs. b Hydrodynamic size of SiO2 NPs, stober SiO2 NPs, SiO2 FPs, and stober SiO2 FPs. c Zeta potential of SiO2 NPs, stober SiO2 NPs, SiO2 FPs, and stober SiO2 FPs. d Silicon concentrations in blood after oral administration of different dose of fumed SiO2 NPs to mice. * P < 0.05 vs. the control group. # P < 0.05 vs. the 25 mg/kg group. $ P < 0.05 vs. the 50 mg/kg group. @ P < 0.05 vs. the 100 mg/kg group (n = 5). e Silicon concentrations in tissues after oral administration of different dose of fumed SiO2 NPs to mice for 18 weeks. * P < 0.05, *** P < 0.001 vs. the control group. Results are the mean ± SE (n = 10). f Silicon concentrations in blood after oral administration of fumed SiO2 NPs, stober SiO2 NPs, SiO2 FPs, and stober SiO2 FPs to mice. * P < 0.05 vs. the control group. # P < 0.05 vs. the Fumed FPs group. $ P < 0.05 vs. the stober FPs group (n = 5). g Silicon concentrations in tissues after oral administration of fumed SiO2 NPs, stober SiO2 NPs, SiO2 FPs, and stober SiO2 FPs to mice for 18 weeks. * P < 0.05, *** P < 0.001 vs. the control group. Results are the mean ± SE (n = 10). h SEM (nanosized spherical white objects are SiO2 NPs) and EDXA (arrows indicate silicon) of tissue homogenates after oral administration of different dose of fumed SiO2 NPs to mice for 18 weeks. i SEM (spherical white objects are SiO2 NPs or FPs) and EDXA (arrows indicate silicon) of tissue homogenates after oral administration of different dose of fumed SiO2 NPs, stober SiO2 NPs, SiO2 FPs, and stober SiO2 FPs to mice for 18 weeks

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