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Fig. 3 | Particle and Fibre Toxicology

Fig. 3

From: Silicon dioxide nanoparticles induce insulin resistance through endoplasmic reticulum stress and generation of reactive oxygen species

Fig. 3

Oral administration of 100 mg/kg bw SiO2 FPs (fine-particles) did not result in elevated blood glucose via induction of IR (insulin resistance) in mice. a Blood glucose levels in blood from mice tail veins after mice orally administrated with fumed SiO2 NPs, stober SiO2 NPs, fumed SiO2 FPs, stober SiO2 FPs. b Blood insulin levels in blood from mice tail veins after mice orally administrated with fumed SiO2 NPs, stober SiO2 NPs, fumed SiO2 FPs, stober SiO2 FPs. c Time course of changes, including the AUC (area under the curve), in blood glucose levels during the OGTT at week 10. d Time course of changes, including the AUC, in blood insulin levels during the OGTT at week 10. e Time course of changes, including the AUC, in blood glucose levels during the ITT at week 10. f Time course of changes, including the AUC, in blood glucose levels during the OGTT at week 18. g Time course of changes, including the AUC, in blood insulin levels during the OGTT at week 18. h Time course of changes, including the AUC, in blood glucose levels during the ITT at week 18. * P < 0.05 vs. the control group. Results are the mean ± SE (n = 10)

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Particle and Fibre Toxicology

ISSN: 1743-8977

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