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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Silicon dioxide nanoparticles induce insulin resistance through endoplasmic reticulum stress and generation of reactive oxygen species

Fig. 5

Oral administration of 100 mg/kg of SiO2 NPs (nanoparticles) increased blood glucose starting at week 10, and inhibition of ER stress and reduced ROS production inhibited increased blood glucose levels. a Blood glucose. b Blood insulin. c Time course of changes, including the AUC, in blood glucose levels during the OGTT at week 10. d Time course of changes, including the AUC, in blood insulin levels during the OGTT at week 10. e Time course of changes, including the AUC, in blood glucose levels during the ITT at week 10. f Protein expression of cleaved caspase 3, and phosphorylation of IRS1 and Akt. g Ratios of cleaved caspase 3/β-actin, p-IRS1/IRS1, and p-Akt/Akt. * P < 0.05 vs. the control group. Results are the mean ± SE (n = 10)

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