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Fig. 7 | Particle and Fibre Toxicology

Fig. 7

From: Silicon dioxide nanoparticles induce insulin resistance through endoplasmic reticulum stress and generation of reactive oxygen species

Fig. 7

Oral administration of 100 mg/kg of SiO2 NPs (nanoparticles) induced ER stress starting at week six, and inhibition of ROS production did not reduce ER stress. a Fold change of genes associated with ER stress, as determined by RNA-seq. b Messenger RNA expression of GRP78. c Messenger RNA expression of CHOP. d The ratio of mRNA expression of sheared-XBP1/total-XBP1 (XBP1-s/t). e Messenger RNA expression of Cyp2b9. f AGE results of XBP1. g The ratio of XBP1-s/t in AGE results. h Protein expression of ER stress markers. i Ratios of ER stress markers. * P < 0.05, ** P < 0.01 vs. the control group. Results are the mean ± SE (n = 10)

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Particle and Fibre Toxicology

ISSN: 1743-8977

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