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Fig. 8 | Particle and Fibre Toxicology

Fig. 8

From: Silicon dioxide nanoparticles induce insulin resistance through endoplasmic reticulum stress and generation of reactive oxygen species

Fig. 8

Relief of ER stress and reduction in ROS levels reduced activation of the NF-κB and MAPK pathways, and blunted the inflammatory response in the livers of mice following oral administration of 100 mg/kg bw of SiO2 NPs. a Fold change of genes related to inflammatory responses, as determined by RNA-seq. b Genes were validated by RT-qPCR. c Protein phosphorylation of NF-κB-p65, IκBα, JNK, and p38-MAPK. d Ratios of p-P65/P65, p-IκBα/ IκBα, p-JNK/JNK, and p-P38/P38. e Levels of TNF-α and IL-6 in mouse sera. * P < 0.05 vs. the control group. Results are the mean ± SE (n = 10)

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Particle and Fibre Toxicology

ISSN: 1743-8977

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