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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: Role of Nrf2 in inflammatory response in lung of mice exposed to zinc oxide nanoparticles

Fig. 1

Representative micrographs of H&E-stained lung sections at post-exposure day 14. a Nrf2+/+ no ZnO-NPs, no inflammation is detected around blood vessels (arrows) or bronchioles (asterisk); b Nrf2+/+ 10 μg ZnO-NPs, bronchioles (asterisk) and vessels (arrows) are surrounded by a thin layer (1–5 cells thick) of inflammatory cells; c Nrf2+/+ 30 μg ZnO-NPs, bronchioles (asterisks) and vessels (arrows) are surrounded by a thick layer (> 5 cells thick) of inflammatory cells; d Nrf2−/− no ZnO-NPs, no inflammation around bronchioles is detected (asterisk); e Nrf2−/− 10 μg ZnO-NPs, vessels (arrow) are surrounded by a thin layer (1–5 cells thick) of inflammatory cells; f Nrf2−/− 30 μg ZnO-NPs, bronchioles (asterisk) are surrounded by a thick layer (> 5 cells thick) of inflammatory cells with lymphoid follicle formation (arrow)

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