Fig. 4
From: Is aggregated synthetic amorphous silica toxicologically relevant?
Estimated concentration reaching the bottom of the wells after 24 h as a function of nominal concentrations applied in cell based assays. Dosimetry simulation was performed by a distorted grid (DG) model and compared for different SAS suspensions using parameters obtained from exposure media DMEM/F12 (a and b) and RPMI 1640 (c and d). The slope values are indicated near the respective lines. R2 > 0.9 for all the suspensions. The percentage of dose delivered to the cells did not differ in 96 or 24 well plates, as the height of the liquid column was equal (6 mm)