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Table 3 Summary of the in vitro responses to SAS exposure

From: Is aggregated synthetic amorphous silica toxicologically relevant?

Biological endpointsAGGRDE-AGGRSuperNPREC
HBECaco2THP1HBECaco2THP1HBECaco2THP1HBECaco2THP1
Cell metabolic activityNoYesYesYesYesYesNoYesYesNoNoYes
Cell viabilityYesNoYesYesYesYesNoYesYesNoNoNo
GSHYesYesYesYesYesYesYesYesYesNoNoNo
TEERYesNon/aYesYesn/aYesYesn/aNoNon/a
IL-8NoYesYesYesYesYesYesYesYesYesNoNo
IL-6NoNoNoYesYesNoYesNoNoYesNoNo
  1. “Yes” indicates p < 0.05 (One-way ANOVA) and there is a significant difference compared to control at any of the tested concentrations; “No” indicates when p > 0.05 and no difference compared to control; n/a - not available