Is aggregated synthetic amorphous silica toxicologically relevant?

Table 3 Summary of the in vitro responses to SAS exposure

Biological endpoints	AGGR			DE-AGGR			SuperN			PREC
Biological endpoints	HBE	Caco2	THP1	HBE	Caco2	THP1	HBE	Caco2	THP1	HBE	Caco2	THP1
Cell metabolic activity	No	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	No	No	Yes
Cell viability	Yes	No	Yes	Yes	Yes	Yes	No	Yes	Yes	No	No	No
GSH	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	No	No	No
TEER	Yes	No	n/a	Yes	Yes	n/a	Yes	Yes	n/a	No	No	n/a
IL-8	No	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	No	No
IL-6	No	No	No	Yes	Yes	No	Yes	No	No	Yes	No	No

“Yes” indicates p < 0.05 (One-way ANOVA) and there is a significant difference compared to control at any of the tested concentrations; “No” indicates when p > 0.05 and no difference compared to control; n/a - not available

ISSN: 1743-8977