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Table 1 Effect of TiO2 NPs on oxidative stress biomarkers in the liver tissue and inflammatory cytokines in serum of rats after oral exposure for 90 days

From: Hepatotoxicity and the role of the gut-liver axis in rats after oral administration of titanium dioxide nanoparticles

 

Control

TiO2 NPs treated doses (mg/kg BW)

2

10

50

GSH (nmol/mg protein)

19.81 ± 4.60

21.20 ± 5.62

18.51 ± 3.80*

17.28 ± 3.48*

GSSG (nmol/mg protein)

8.82 ± 1.27

9.69 ± 1.53

9.45 ± 1.31*

9.28 ± 2.13*

GSH/GSSG

2.23 ± 0.23

2.18 ± 0.44

1.95 ± 0.22*

1.88 ± 0.23*

GSH-Px (mU/mg protein)

161.18 ± 11.43

192.84 ± 57.97

205.05 ± 40.47*

210.04 ± 82.34*

MDA (nmol/mg protein)

3.40 ± 2.21

3.02 ± 2.49

11.82 ± 17.49

43.80 ± 27.51*

SOD (U/mg protein)

10.56 ± 1.06

12.62 ± 4.76

13.64 ± 2.93*

14.84 ± 6.30

IL-1α (pg/mL)

11.48 ± 2.34

10.35 ± 0.64

11.40 ± 1.23

13.41 ± 2.54*

IL-4 (pg/mL)

1.35 ± 0.11

1.40 ± 0.18

1.42 ± 0.13

1.83 ± 1.38*

TNF (pg/mL)

13.69 ± 1.57

13.43 ± 2.80

14.36 ± 2.30

13.51 ± 1.43*

  1. * Significant difference compared to the control group (p < 0.05). NPs nanoparticles, BW body weight, GSH reduced glutathione, GSH-Px glutathione peroxidase, GSSG oxidized glutathione, MDA malondialdehyde, lipid peroxidation products, SOD superoxide dismutase, IL interleukin, TNF tumor necrosis factor