Particle and Fibre Toxicology

Table 3 Bronchoalveolar lavage fluid cell counts in Brown Norway rats

From: Inhalation of welding fumes reduced sperm counts and high fat diet reduced testosterone levels; differential effects in Sprague Dawley and Brown Norway rats

	Total cell number (10⁶)	Macrophages (10⁶)	Neutrophils (10⁶)
Week 12 – exposure
Air + Reg	12.8 + 1.2	12.7 + 1.1	0.14 + 0.1
Air + HF	8.7 + 0.2	8.7 + 0.2	0.00 + 0.0
GMA-SS + Reg	62.1 + 4.4 ^ab	52.4 + 4.2 ^ab	9.66 + 2.6 ^ab
GMA-SS + HF	76.5 + 4.7 ^ab	68.9 + 3.7 ^ab	7.39 + 1.3 ^ab
Week 24 – recovery
Air + Reg	18.0 + 2.3	18.0 + 2.3	0.04 + 0.04
Air + HF	14.4 + 3.3	14.4 + 3.3	0.00 + 0.0
GMA-SS + Reg	43.2 + 3.1 ^ab	28.4 + 2.5 ^ab	14.9 + 2.1 ^ab
GMA-SS + HF	49.9 + 6.6 ^ab	35.7 + 4.1 ^ab	14.2 + 2.8 ^ab

Total cells number, macrophages and neutrophils in the bronchoalveolar lavage fluid from Brown Norway rat lungs at week 12 after a 5-week exposure to 20 mg/m³ of GMA-SS, and at week 24 after a 12 week recovery period. Mean ± SD (n = 6). Significant effects are highlighted in bold
^aSignificantly different from Air+Reg diet (p < 0.05)
^bSignificantly different from Air+HF diet (p < 0.05)

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ISSN: 1743-8977

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