Fig. 11From: Silica nanomaterials induce organ injuries by Ca2+-ROS-initiated disruption of the endothelial barrier and triggering intravascular coagulationConfocal images showing the toxic effects of SiNPs (35 mg/kg, i.v.) on the expression and spatial localization of VE-cadherin (green) in the heart, lung, liver and kidney of mice in vivo. Nuclei were stained blue with DAPI. Compared to the control tissues which showed a homogenous and dotted pattern of VE-cadherin distribution, mice exposed to SiNP-20 or SiNP-100 for 72 h showed decreased expression, and disrupted distribution, of VE-cadherin, in these organ tissues. Scale bar = 100 μmBack to article page