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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Silica nanomaterials induce organ injuries by Ca2+-ROS-initiated disruption of the endothelial barrier and triggering intravascular coagulation

Fig. 5

The inhibitory effects of SiNPs on endothelial migration and tube formation. a, b and c, transwell assays showing the effects of SiNP-20 (a) and SiNP-100 (b) on the migration of HUVECs. c, statistical results of migration (n = 3 independent assays). Both SiNP-20 and SiNP-100 decreased cell migration roughly in a concentration (0–100 μg/mL)-dependent manner, and SiNP-100 was more potent than SiNP-20 in suppressing the migration. ** p < 0.01 vs. control. #p < 0.05 vs. SiNP-20. d, e and f, confocal results showing the inhibitory effects of SiNP-20 (d) and SiNP-100 (e) on the tube formation of HUVECs. Statistical results of tube numbers were shown in (f) (n = 3 independent assays). Both SiNP-20 and SiNP-100 suppressed the tubule formation in a concentration (0–100 μg/mL) dependent manner. SiNP-100 was more toxic than SiNP-20 on the tube formation. ** p < 0.01, *** p < 0.001 vs. control. #p < 0.05 vs. SiNP-20. Scale bar = 50 μm

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Particle and Fibre Toxicology

ISSN: 1743-8977

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