Skip to main content

Table 4 The IC50 and ID50 of AgNPs and AgNO3 after 24 and 120 h exposure in mESCs

From: Combination of the BeWo b30 placental transport model and the embryonic stem cell test to assess the potential developmental toxicity of silver nanoparticles

 

IC50 (mg/L) (24 h)

IC50 (mg/L) (120 h)

ID50 (mg/L)

Calculated concentration of dissolved Ag+ (mg/L) in ID50 (120 h)

Calculated % of inhibition of differentiation induced by dissolved Ag+

(LA) AgNPs

100

0.9

13

4.16

22.5%

(Cit) AgNPs

100

0.38

16

4.96

31%

(BPEI) AgNPs

30

0.8

8

2.24

16%

Ag2S NPs

> 100

29

> 100

25

N.A.

AgNO3

25

0.33

9.5

–

–

  1. IC50 the concentration where 50% of mESCs are viable
  2. ID50 the concentration of 50% inhibition of differentiation of EBs into beating cardiomyocytes
  3. N.A. Not applicable
Back to article page

Particle and Fibre Toxicology

ISSN: 1743-8977

Contact us