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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale

Fig. 1

Adverse outcome pathways (AOPs) of relevance to nanomaterials. All AOPs, except one, are on the OECD EAGMST AOP work plan and are identified by the respective AOP IDs. Some AOP titles and KE descriptions may differ from how they appear on the AOPwiki. Some AOPs also include events called associative events that perpetuate the response towards adverse outcome and may be used to measure the specific KEs. Solid arrows denote adjacency (adjacent KEs occur in succession consequently to one another or immediately upstream and downstream of one another in an AOP), dashed arrows depict associative events and contiguous arrows show non-adjacency (non-adjacent KEs are further apart from each other and have other KEs in between). Green: molecular initiating events; Orange: cellular level key events; Purple: tissue level key events; Red: adverse outcomes

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