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Fig. 8 | Particle and Fibre Toxicology

Fig. 8

From: Pro-inflammatory effects of crystalline- and nano-sized non-crystalline silica particles in a 3D alveolar model

Fig. 8

Effect of IL-1RA on CXCL8, IL-6, IL-1α, IL-1β and TNF-α gene expression after exposure to Si10 or Min-U-Sil in 3D tri-cultures. The figure shows gene expression on the apical versus the basolateral side of the 3D tri-culture. Cells in the apical compartment were pre-treated for 1 h with and without interleukin-1 receptor antagonist (IL-IRA; 30 μg/ml), and exposed for 10 h with and without Si10 (24 μg/cm2) or Min-U-Sil (192 μg/ cm2.) in the presence of the antagonist. Gene expression was determined by qPCR and represent the mean +/− of 3 independent experiments. *Statistical significant difference from control, #statistically significantly different from exposure without IL-1RA, P < 0.05

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