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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes

Fig. 1

nanoSiO2 accumulates in heart tissue, diminishing contractility and affecting predominantly LVP and HR. a Silicon quantification in myocardial tissue by SEM-EDS after 100 μg/mL nanoSiO2 perfusion in ex-vivo heart. b, c Heart rate pressure product (RPP = HR × LVP) during 60 min after time- and dose- dependent nanoSiO2 administration. d The RRP dependence on nanoSiO2 administration reduced the frequency, and in some cases the amplitude of LVP and dP/dt, in addition a reduced HR. Values are percentage of control and represent mean ± SEM, n = 4

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Particle and Fibre Toxicology

ISSN: 1743-8977

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