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Table 2 Ex vivo perfused hearts with nanoSiO2, present reduced RPP, LVP and HR and –dP/dt

From: Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes

 

Control

nanoSiO2

p-value

RPP (%)

99.4 ± 1.9

46.6 ± 13.6

0.009

LVP (mmHg)

105.3 ± 4

96.6 ± 4.4

0.194

HR (bpm)

313 ± 6

142 ± 14

< 0.001

+dP/dt (mmHg/s)

2018 ± 20

2049 ± 84

0.731

-dP/dt (mmHg/s)

− 1581 ± 12

− 1309 ± 62

0.005