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Table 2 Ex vivo perfused hearts with nanoSiO2, present reduced RPP, LVP and HR and –dP/dt

From: Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes

 ControlnanoSiO2p-value
RPP (%)99.4 ± 1.946.6 ± 13.60.009
LVP (mmHg)105.3 ± 496.6 ± 4.40.194
HR (bpm)313 ± 6142 ± 14< 0.001
+dP/dt (mmHg/s)2018 ± 202049 ± 840.731
-dP/dt (mmHg/s)− 1581 ± 12− 1309 ± 620.005