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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Quantitative biokinetics over a 28 day period of freshly generated, pristine, 20 nm silver nanoparticle aerosols in healthy adult rats after a single 1½-hour inhalation exposure

Fig. 4

Daily urinary excreted fractions of [105Ag]Ag -activity after intratracheal inhalation of [105Ag]AgNP derived from the dissection time points 7 and 28 days p.e. Data are given as fractions of ILD. Panel a shows the daily excreted fractions of [105Ag]Ag activity; panel b shows the cumulative kinetics. For the 28 days group, the urine samples were collected over 3–4 days and the measured values were divided by the number of sampling days and associated with the mean day of the sample interval. Mean ± SEM, n = 4 rats per time point. Panel c: [105Ag]Ag activity fraction translocated across the ABB presented as stacked columns with contributions from major secondary organs, the carcass, and cumulative urine normalized to ILD of [105Ag]AgNP. Translocated [105Ag]Ag activity accumulated predominantly in the carcass and liver within the first 24 h p.e., the fraction excreted via urine increases rapidly from 7 to 28 days p.e. Mean ± SEM, n = 4 rats per time point

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Particle and Fibre Toxicology

ISSN: 1743-8977

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