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Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: Quantitative biokinetics over a 28 day period of freshly generated, pristine, 20 nm silver nanoparticle aerosols in healthy adult rats after a single 1½-hour inhalation exposure

Fig. 6

Kinetics of [105Ag]Ag -activity concentrations per weight of organ or tissue after intratracheal inhalation of [105Ag]AgNP. Panel a: total translocation and blood, Panel b: liver, spleen, and kidneys, Panel c: heart, uterus, and brain, Panel d: carcass and translocation. The mean ILD in mass (number) of [105Ag]AgNP for all five retention time points is 25.6 ± 6.9 μg (7.94 ± 3.24•1011 #). Data are corrected for [105Ag]Ag activity retained in the residual blood volume of organs and tissues and correspond to the second line of each organ in Table 4; data are presented as mean ± SEM; n = 4 rats per time point. Data points for both groups of rats at 0.75 and 24 h are set slightly aside from each other for easier distinction of the highly reproducible data obtained. Statistical one-way ANOVA analysis with the post-hoc Bonferroni test in between all time-points are given in the matrix below

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Particle and Fibre Toxicology

ISSN: 1743-8977

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