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Table 2 [105Ag]AgNP Aerosol parameters (mean ± SD; n = 4 of each group) during the entire intratracheal inhalation time of 1.5 h of each exposure

From: Quantitative biokinetics over a 28 day period of freshly generated, pristine, 20 nm silver nanoparticle aerosols in healthy adult rats after a single 1½-hour inhalation exposure

Group of rats

Instrument

0.75 h(1st)

0.75 h(2nd)

4 h

24 h(1st)

24 h(2nd)

7d

28d

CMD (nm), mean ± SD of 40 spectra. a

SMPS1

21.9 ± 0.7

21.4 ± 0.6

21.7 ± 1.4

22.1 ± 0.1

23.8 ± 3.3

21.8 ± 0.9

21.4 ± 0.5

CMD (nm) of aver-aged extrapolated spectrumb

SMPS

20.7

20.4

20.2

20.6

20.2

20.5

22.4

Geom. Std. Dev. (GSD) mean ± SD of 30 spectraa

SMPS

1.42 ± 0.01

1.42 ± 0.01

1.42 ± 0.01

1.43 ± 0.02

1.45 ± 0.06

1.43 ± 0.01

1.42 ± 0.01

GSD of averaged extrapolated spectrumb

SMPS

1.42

1.41

1.41

1.41

1.41

1.41

1.49

Number concentration (# × 106/cm3) of all 30 spectra b

SMPS

6.5 ± 0.8

5.8 ± 0.7

5.53 ± 1.11

6.6 ± 0.6

6.7 ± 0.8

6.2 ± 0.5

6.1 ± 0.7

Median diameter (nm) of volume concentration of all 30 spectra

SMPS

31.0 ± 1.1

30.8 ± 1.1

32.8 ± 3.4

32.4 ± 1.3

32.3 ± 0.44

32.6 ± 1.1

30.9 ± 0.8

Volume concentration c (# × 109 nm3/cm3)

SMPS

59.2 ± 9.6

50.9 ± 9.3

50.9 ± 2.2

66.5 ± 10.5

69.4 ± 9.1

62.7 ± 10.3

54.2 ± 8.7

Number concentration (# × 106/cm3)

CPC

7.9 ± 0.3

8.5 ± 0.4

7.0 ± 0.5

7.7 ± 0.2

8.2 ± 0.5

11.6 ± 11.9

8.0 ± 0.3

Specific 105Ag aerosol activity on filter (kBq/L)d

γ-spectro metry

3.41

2.80

3.80

2.64

2.20

2.69

2.24

Aerosol mass conc (μg/L) from elec-trode + filter actd

γ-spectro metry

1.31

1.46

1.01

1.03

0.86

1.08

0.85

  1. 1 AIM - Instrument Manager Software of TSI Inc. version 7.2.5.0
  2. a Mean of count median diameters (CMD) and geometric standard deviations (GSD) of all 30 SMPS spectra measured in the size range 10 nm - 420 nm
  3. b CMD and GSD of the number size spectrum averaged over all 30 SMPS spectra and mean-square fitted and extrapolated to 1-nm size; see Supplementary Information
  4. c Integral particle volume concentration (PVC) of the aerosol distribution (cm3/m3) SMPS derived
  5. d Specific [105Ag]AgNP aerosol activity determined from an aerosol filter sample continuously collected during each 1.5-h exposure at 0.3 L/min according to Eq. 1 of Supplementary Information
  6. # Derived [105Ag]AgNP aerosol mass concentration (μg/L) dividing the specific 105Ag aerosol activity of the filter (, kBq/L) by the specific [105Ag]AgNP activity concentration 2.60 kBq/μg of the Ag-electrodes used for spark-ignition aerosol generation