Table 6 Summarized data on the significant differences in analysis results
From: Oral toxicity of titanium dioxide P25 at repeated dose 28-day and 90-day in rats
Period | Significant differences (vs. G1) | Results |
|---|---|---|
28-day | • Urinalysis | • No dose-response correlation • Within biological normal ranges • Temporary or isolated symptoms without subsequent changes → No relationship with the test substance |
- SG (male – G2, 3, 4) | ||
• Hematological values | ||
- LY (female – G2, 3, 4) ↓ | ||
- MCV (female – G2) ↑ | ||
• Serum biochemical values | ||
- Cl (female – G3) ↑ | ||
• Absolute organ weight | ||
- Right adrenal glands (male – G2, 4) ↓ | ||
- Livers (female – G2) ↑ | ||
90-day | • Detailed clinical observations | |
- Defecation (male in week-4) | ||
- Urination (female in week-12) | ||
• Food consumption (male in week-8 – G3) ↓ | ||
• Hematological values | ||
- NE (female – G3) ↓ | ||
- NEP (female – G2, 3, 4) ↓ | ||
- LYP (female – G2, 3, 4) ↑ | ||
• Serum biochemical values | ||
- BUN (female – G4) ↓ | ||
Recovery (for 28 days) | • Water intake (male in week-17 – G4) ↓ | |
• Serum biochemical values | ||
- Na (male – G4) ↓ | ||
• Absolute organ weight | ||
- Pituitary glands (male – G4) ↑ | ||
- Uterus (female – G4) ↓ | ||
• Relative organ weight | ||
- Liver (female – G4) ↑ |