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Fig. 2 | Particle and Fibre Toxicology

Fig. 2

From: Caloric restriction attenuates C57BL/6 J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure

Fig. 2

CR protects against PM-induced pulmonary injury. Al-fed and CR-fed mice were exposed to PM for 4 weeks. a Representative images of H&E staining (magnification, 200×) and TUNEL staining of lung tissues (magnification, 400×) in different groups of mice. The typical pathological changes, including neutrophil infiltration (★), alveolar septal thickening (◆), alveolar hemorrhage (▲) were indicated. The lung injury scores (b), the number of tunnel positive cells (c) in mouse lung tissues. n = 10 per group. The total cell number (d), the levels of lactate dehydrogenase (LDH) (E), the total protein contents (TP) (f), and albumin contents (ALB) (g) in mouse bronchoalveolar lavage fluid (BALF). n = 10 per group. h-i Immunoblotting analysis presents the levels of cleaved caspase-3 in mouse lung tissues. n = 3 per group. The data are expressed as the mean ± SD. *P < 0.05 (AF vs. PM), &P < 0.05 (CR-AF vs. AL-AF), #P < 0.05 (CR-PM vs. AL-PM)

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Particle and Fibre Toxicology

ISSN: 1743-8977

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