Skip to main content
Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Caloric restriction attenuates C57BL/6 J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure

Fig. 4

Signature of gene expression and functional alternations altered by CR in mouse lung tissues. Ingenuity Pathway Analysis (IPA) reveals differentially expressed genes (DEGs) in mouse lung tissues of AL- and CR-fed mice with or without PM exposure. The comparison of the categories of disease and toxicological effects involved in organ injury and abnormalities, respiratory disease, inflammation, cell death and survival between CR-AF and AL-AF mice (a) and between CR-PM and AL-PM mice (b). The comparison of the key canonical pathways involved in inflammatory response, oxidative stress, DNA damage, and xenobiotic metabolism between CR-AF and AL-AF (c) and between CR-PM and AL-PM mice (d). n = 3 per group

Back to article page