Fig. 6From: Caloric restriction attenuates C57BL/6 J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposurePerturbation of canonical pathways were reversed by CR in mouse livers. Comparison of the 20 most significant canonical pathways identified by IPA analysis between CR-AF and AL-AF mice (a) and between CR-PM and AL-PM mice (b). Molecular pathways involved in xenobiotic metabolism include AhR signaling (c), NRF2-mediated oxidative stress response (d), RXR activation (e-f), and glutathione-mediated detoxification (g). Circles filled in pink colors indicate a trend of upregulations, while circles filled in green colors indicate a trend of downregulations in CR-fed mice with or without PM exposure. n = 3 per groupBack to article page