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Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: Caloric restriction attenuates C57BL/6 J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure

Fig. 6

Perturbation of canonical pathways were reversed by CR in mouse livers. Comparison of the 20 most significant canonical pathways identified by IPA analysis between CR-AF and AL-AF mice (a) and between CR-PM and AL-PM mice (b). Molecular pathways involved in xenobiotic metabolism include AhR signaling (c), NRF2-mediated oxidative stress response (d), RXR activation (e-f), and glutathione-mediated detoxification (g). Circles filled in pink colors indicate a trend of upregulations, while circles filled in green colors indicate a trend of downregulations in CR-fed mice with or without PM exposure. n = 3 per group

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