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Fig. 7 | Particle and Fibre Toxicology

Fig. 7

From: Caloric restriction attenuates C57BL/6 J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure

Fig. 7

CR enhances the activities of xenobiotic metabolism and detoxification of PM-bound PAHs. a The induction of CYP1A1, CYP1A2, CYP1B1, GSTT1, GSTM1, and UGT1A1 in mouse liver tissues of AL- and CR-fed mice with (Exp) or without (Con) PM exposure. n = 3 per group. The quantitative analysis of CYP1A1 (b), CYP1A2 (c), CYP1B1 (d), GSTT1 (e), GSTM1 (f), and UGT1A1(g) in different groups of mice. The concentration of urinary hydroxylated metabolites of PAHs (OH-PAHs), 1-OHNap (h), 2-OHNap (i), 1-OHPhe (j), 4-OHPhe (k), 9-OHPhe (l), 2-OHFlu (m), and 1-OHPyr (n) in different groups of mice. n = 3 per group. The data are expressed as the mean ± SD, *P < 0.05 (AF vs. PM), &P < 0.05 (CR-AF vs. AL-AF), #P < 0.05 (CR-PM vs. AL-PM)

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Particle and Fibre Toxicology

ISSN: 1743-8977

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