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Table 1 Outcome data from tables and figures from Beck et al. 1987.*

From: Analysis of particles from hamster lungs following pulmonary talc exposures: implications for pathogenicity

Parameters

Day 1

Day 4

Day 7

Day 14

BAL Cell Counts with 3.75 mg/100 g Body Weight Intra-tracheal (IT) Dose

 Macrophages (Cell Number per total lavage volume, × 106)

Talc

5.5 ± 0.3 (NS)

10 (NS)

8 (NS)

10 (S)

Granite

6.7 ± 1.0 (S)

13 (S)

13 (S)

13 (S)

Control

6.0 ± 0.5

6.5

6

6.2

 Neutrophils (Cell Number per total lavage volume, ×106)

Talc

11.7 ± 1.1 (S)

4 (S)

4 (S)

4 (S)

Granite

20 ± 2.8 (S)

15 (S)

4 (S)

0.8 (S)

Control

1.5 ± 0.6

0.3

0.1

0.2

BAL fluid Analyses with 3.75 mg/100 g Body Weight IT Dose

 Lactic Dehydrogenase (mU/ml Lavage fluid)

Talc

139 ± 15 (S)

80 (S)

65 (NS)

55 (S)

Granite

125 ± 7 (S)

59 (S)

43 (S2)

37 (S2)

Control

19 ± 1

22

25

21

 Peroxidase (mU/ml Lavage fluid)

Talc

210 ± 37 (S)

N/A

N/A

N/A

Granite

196 ± 36 (S)

N/A

N/A

N/A

Control

2 ± 2 ± 0.3

N/A

N/A

N/A

ß-N-Acetyl Glucosaminidase (mU/ml Lavage fluid)

Talc

159 ± 9 (S)

80 (S)

82 (S)

84 (S)

Granite

187 ± 21 (S)

40 (S)

35 (S)

30 (S5)

Control

25 ± 6

26

23

28

 Albumin (μg/ml Lavage Fluid)

Talc

1380 ± 116 (S)

N/A

N/A

N/A

Granite

2130 ± 262 (S)

N/A

N/A

N/A

Control

66 ± 4

N/A

N/A

N/A

In vivo Phagocytosis: Lambda assay uptake of labeled Particles after IT dust (3.75 mg/100 g Body Wt Dose)

 Lambda: Fraction of Radioactive Gold Particles Phagocytized

Talc

0.46 ± 0.07 (S)

0.56 (S)

0.54 (S5)

0.52 (S2)

Granite

0.47 ± 0.10 (S)

0.85 (S5)

0.82 (NS)

0.7 (NS)

Control

0.66 ± 0.3

0.75

0.73

0.78

  1. * All data from figures are estimates of the means. When these data were also present in tables, the estimates were never more than 2% different from the numbers available in the tables; table data are shown if both were available. All data with distributions are shown as Mean ± SEM. N/A indicates data were not available from the Beck et al. paper. All statistical analyses are shown as p value of difference from control (C). NS indicates not significantly different from control. S indicates significantly different from control, S1p < 0.01 vs control. S2, p < 0.02 vs control, S5 p < 0.05 vs control