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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Jejunal villus absorption and paracellular tight junction permeability are major routes for early intestinal uptake of food-grade TiO2 particles: an in vivo and ex vivo study in mice

Fig. 4

Quantification of the TiO2 absorption in vivo in the mouse intestine and blood at 0 h (control animals fed with water), or at 2 h, 4 h or 8 h after gavage. Number of detected particles counted: a in jejunal and ileal villi, in colon crypts and jejunal PP at 0 h (ctrl), 4 and 8 h after feeding; being expressed in Particles (P)/(1000xmm3 of tissue). Significant difference *** (p < 0.001) between values at 0 h versus 4 h in jejunal villi and 0 h versus 8 h in the PP (b, c) TiO2 detection in blood. b Confocal detection of TiO2 in green in blood smears recovered at 0 h, 4 h and 8 h after feeding. TiO2 are visible in green (as indicated with green arrows) and RBC in red. c Particle quantification expressed in millions of P/ml of blood; ***: significant increase for the times 4 h and 8 h as compared to 0 h (p < 0.001). d Quantification by ICP-MS of titanium contents in the jejunum, ileum and colon after in vivo absorption at 0 h, 4 h and 8 h after TiO2 oral administration, expressed in mg of titanium/kg of tissue. ***: significant increase as compared to 0 h (p < 0.001)

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Particle and Fibre Toxicology

ISSN: 1743-8977

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