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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Jejunal villus absorption and paracellular tight junction permeability are major routes for early intestinal uptake of food-grade TiO2 particles: an in vivo and ex vivo study in mice

Fig. 5

Effect of diet lipids on TiO2 absorption in vivo. a Quantification of TiO2 absorption in jejunal villi recovered 4 h after forced-feeding with 40 mg/ml of TiO2 in aqueous medium (W for Water) or in oil emulsion (O), in villi from control mouse fed with water (0 h) and (b) confocal identification of the distribution of TiO2 (green) at 4 h in the villi of oil fed mouse, the absorbed lipids (chylomicrons or lipid droplets) are stained in red by LD540 and are abundant in the epithelial monolayer (Epith) situated between the lamina propria (LP) and the lumen (L). Bars = 10 μm

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