TY - JOUR AU - Hickey, Christina AU - Gordon, Christopher AU - Galdanes, Karen AU - Blaustein, Martin AU - Horton, Lori AU - Chillrud, Steven AU - Ross, James AU - Yinon, Lital AU - Chen, Lung Chi AU - Gordon, Terry PY - 2020 DA - 2020/07/02 TI - Toxicity of particles emitted by fireworks JO - Particle and Fibre Toxicology SP - 28 VL - 17 IS - 1 AB - Particle matter (PM) has been associated with increased morbidity and mortality rates across the world. This study was designed to test the hypotheses that pyrotechnic firework displays introduce significant amounts of toxic metals into the atmosphere and are hazardous to human health. Size-selective emissions from 10 different fireworks displays were collected during particle generation in a dynamic, stainless steel chamber and tested for toxicity in cells. A subset of 2 particle types were tested in vivo in mice. At doses that did not produce cytotoxicity in an LDH assay, in vitro reactive oxygen species (ROS) formation was measured in bronchial epithelial airway (BEAS-2B) and human pulmonary microvascular endothelial (HPMEC-ST1.6R) cell lines treated with size-fractionated particles from the emissions of fireworks. SN - 1743-8977 UR - https://doi.org/10.1186/s12989-020-00360-4 DO - 10.1186/s12989-020-00360-4 ID - Hickey2020 ER -