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Fig. 8 | Particle and Fibre Toxicology

Fig. 8

From: Serum-borne factors alter cerebrovascular endothelial microRNA expression following particulate matter exposure near an abandoned uranium mine on the Navajo Nation

Fig. 8

Pathway analysis A) Pathway analysis for upregulated (a) and downregulated (b) miRNAs and their respective mRNA targets. Upregulated genes involved RAF-independent MAPK activation, the MAPK pathway, axon guidance, assembly of collagen fibrils and other multimeric structures and collagen chain trimerization pathways. Downregulated genes involved the RAF/MAP kinase cascade, axon guidance, collapsing response mediator proteins (CRMPs) in Sema 3A signaling and signaling by receptor tyrosine kinases

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