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Fig. 10 | Particle and Fibre Toxicology

Fig. 10

From: Crystalline silica particles cause rapid NLRP3-dependent mitochondrial depolarization and DNA damage in airway epithelial cells

Fig. 10

Inhaled silica particles rapidly induce DNA damage in mice. Pathogen-free mice (6 mice in each group) were exposed by intranasal instillation to silica (25 μg silica suspended in 25 μl PBS /mouse) and for times indicated or to PBS (for 10 or 120 min). a, c Lung tissue was homogenized in RIPA buffer. Tissue homogenate was analyzed by Western blot for NLRP3, pCHK2, γH2AX, ATX, Gprc5a, and CC10. b ELISA analysis of ATX and CC10 of serum and bronchoalveolar lavage (BAL) samples from mice. #p < 0.05, ##p < 0.01, ###p < 0.001 compared to alternatively treated cells, as determined by ANOVA

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Particle and Fibre Toxicology

ISSN: 1743-8977

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