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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Amorphous silica nanoparticles accelerated atherosclerotic lesion progression in ApoE−/− mice through endoplasmic reticulum stress-mediated CD36 up-regulation in macrophage

Fig. 4

Effect of SiNPs on the progression of atherosclerosis. Representative images of a mouse aorta with atherosclerotic plaque (a), and the whole aorta stained by Oil red O was arranged for optimal measurement of lesion area by en-face analysis (b, c). n = 3. d Representative images of H&E, Oil Red O, Alizarin Red and Masson staining in aortic root. Scale bar = 200 μm or 50 μm. e, f The analysis of plaque area and maximum plaque thickness based on H&E and Oil Red O staining, n = 7–9. g The plaque lipid content based on Oil Red O staining, n = 4. h Plaque collagen content based on Masson staining, n = 4. *p < 0.05 vs Control. Data are expressed as means ± SD

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Particle and Fibre Toxicology

ISSN: 1743-8977

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