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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Amorphous silica nanoparticles accelerated atherosclerotic lesion progression in ApoE−/− mice through endoplasmic reticulum stress-mediated CD36 up-regulation in macrophage

Fig. 5

Representative TEM picture of the plaque. Foam cells, migrated smooth muscle cells, and a large quantity of cholesterol crystals and necrotic substances (black arrow) were observed in the lesions of mice in control or SiNPs group. The expansion of endoplasmic reticulum was observed within macrophages inside the lesion (yellow arrow). Scale bar = 1 μm

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