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Fig. 2 | Particle and Fibre Toxicology

Fig. 2

From: Comparative carcinogenicity study of a thick, straight-type and a thin, tangled-type multi-walled carbon nanotube administered by intra-tracheal instillation in the rat

Fig. 2

H&E sections of the lungs of rats treated with MWCNT-A and MWCNT-B. a MWCNT-A in a rat lung at 52 weeks. MWCNT-A is straight-shaped. Fibers in alveolar macrophages can be seen. Arrow points to a free fiber. b MWCNT-A in a rat lung at 104 weeks. Fibers in macrophages and in granulation tissue can be seen. c MWCNT-B in a rat lung at 52 weeks. MWCNT-B has a coarse granular appearance in the cytoplasm of alveolar macrophages. Fibers in granulation tissue and in free macrophages can be seen. d MWCNT-B in a rat lung at 104 weeks. Fibers are mostly encased in granulation tissue. Macrophage aggregates and free macrophages with MWCNT-B fibers can also be seen. Scale bar represents 50 μm

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