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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation

Fig. 1

TiO2-NP treatment reduced claudin-5 protein level in endothelial cells. Representative images and histograms showed the treatment with TiO2-NPs caused an obvious claudin-5 protein degradation in both time-dependent a and mass-dependent b manner. But, the expression level of ZO-1, occludin, CD144 (VE-cadherin) and β-catenin was remained unaltered. c TiO2-NP-mediated claudin-5 protein degradation has been affirmed in HREC, suggested the ocular vascular plexus might be the target while TiO2-NP exposure. ***p < 0.001, indicates statistically significant difference from the control treatment

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