Fig. 7
Intravitreal exposure of TiO2-NPs changed the thickness of retinal sublayers. a SD-OCT scan images were taken from the mice, employing the Micron III retinal imaging microscope. No significant damages were identified in OCT images. b Following the setting of InSight software, the thickness of three retinal sublayers was automatically identified and computed, and expressed as % of total retina thickness. The thickness of inner sublayer, including the nerve fibers layer (NFL), the ganglions, the inner plexiform layer (IPL) and the inner nuclear layer (INL), was reduced at day 7 (0.5 ng/eye) and day 14 (0.25 and 0.5 ng/eye). But, an increased thickness of middle sublayer, comprises the outer plexiform layer (OPL) and the outer nuclear layer (ONL), has been computed at day 7 (0.5 ng/eye) and day 14 (0.25 and 0.5 ng/eye). **p < 0.01, ***p < 0.001, indicates statistically significant difference from the control (day 0)